Lopez was born and raised in Castle Hill, a neighborhood in the Bronx, New York to Puerto Rican parents Guadalupe Rodríguez, a kindergarten teacher, and David Lopez, a computer specialist.[4] She has 2 siblings, Linda and Leslie. Lopez spent her entire academic career in Catholic schools. She financed singing and dancing lessons for herself from the age of nineteen. After leaving a one-semester career at Baruch College, Lopez divided her time between working in a legal office, dance classes, and dance performances in Manhattan clubs at night. After months of auditioning for dance roles, Lopez was selected as a dancer for various rap artists' music videos, a 1990 episode of Yo! MTV Raps, and on the American Music Awards as a backup dancer for the New Kids on the Block and their performance of their song "Games" in 1991. After being rejected twice, Lopez gained her first regular high-profile job as a "Fly Girl" dancer on the television comedy program In Living Color in 1990. Soon after, Lopez became a backup dancer for Janet Jackson and made an appearance in her 1993 video "That's the Way Love Goes".

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